
SARS-CoV-2 Mpro-IN-2
CAS No. 2768834-39-3
SARS-CoV-2 Mpro-IN-2( —— )
Catalog No. M35696 CAS No. 2768834-39-3
SARS-CoV-2 Mpro-IN-2 is a selective SARS-CoV-2M pro inhibitor with an IC50 value of 0.40 μM.SARS-CoV-2 Mpro-IN-2 has good antiviral activity and can be used to study COVID-19.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
2MG | 251 | Get Quote |
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5MG | 392 | Get Quote |
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10MG | 629 | Get Quote |
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25MG | 1214 | Get Quote |
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50MG | 1822 | Get Quote |
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100MG | 2394 | Get Quote |
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500MG | Get Quote | Get Quote |
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1G | Get Quote | Get Quote |
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Biological Information
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Product NameSARS-CoV-2 Mpro-IN-2
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NoteResearch use only, not for human use.
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Brief DescriptionSARS-CoV-2 Mpro-IN-2 is a selective SARS-CoV-2M pro inhibitor with an IC50 value of 0.40 μM.SARS-CoV-2 Mpro-IN-2 has good antiviral activity and can be used to study COVID-19.
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DescriptionSARS-CoV-2 Mpro-IN-2 (compound GC-14) is a selective, low cytotoxic and non-covalent Mpro inhibitor (IC50=0.40 μM) with good anti-SARS-CoV-2 activity (EC50=1.1 μM). SARS-CoV-2 Mpro-IN-2 can be used in COVID-19 studies.
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In VitroSARS-CoV-2 Mpro-IN-2 (0.01-100 μM; 4 h) shows low cytotoxicity in Vero E6 cells.Cell Cytotoxicity Assay Cell Line:Vero E6 cells Concentration:0.01-100 μM Incubation Time:4 h Result:Exhibited low cytotoxicity with a CC50 value of more than 100 μM.
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In VivoSARS-CoV-2 Mpro-IN-2 (2 mg/kg; i.v.; single) exhibits clearance rate (CL), mean residence time (MRT), and half-life (t1/2) are 3140 mL/h/kg, 0.40 h, and 0.36 h, respectively.SARS-CoV-2 Mpro-IN-2 (10 mg/kg; p.o.; single) is rapidly absorbed, with a time-to-maximum concentration (Tmax) of 0.5 h, and shows a moderate pharmacokinetic profile including a favorable t1/2 (1.73 h), a maximum concentration (Cmax) 74.6 ng/mL, and an area under curve (AUC0-t) of 235 ng h/mL.Animal Model:Male Sprague-Dawley rats.Dosage:2 mg/kg (for i.v.); 10 mg/kg (for p.o.).Administration:Intravenous injection or oral administration; single.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorSARS-CoV
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Research Area——
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Indication——
Chemical Information
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CAS Number2768834-39-3
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Formula Weight475.39
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Molecular FormulaC22H20Cl2N4O2S
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Purity>98% (HPLC)
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Solubility——
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SMILESC(NCC1=CC=CS1)(=O)[C@H]2N(CCN(C(=O)C=3C=CC=NC3)C2)C4=CC(Cl)=C(Cl)C=C4
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Gao S, et al. Discovery and Crystallographic Studies of Trisubstituted Piperazine Derivatives as Non-Covalent SARS-CoV-2 Main Protease Inhibitors with High Target Specificity and Low Toxicity. J Med Chem. 2022 Sep 15:acs.jmedchem.2c01146. ?
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